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ea0029p539 | Diabetes | ICEECE2012

GABA A receptor gene regulatory networks in peripheral blood TCD4+, TCD8+ AND CD14+ cells of recently diagnosed type 1 diabetes mellitus

Rassi D. , Evangelista A. , Brum D. , Deghaide N. , Foss-Freitas M. , Foss M. , Sakamoto-Hojo E. , Sanjeevi C. , Passos G. , Donadi E.

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter primarily produced by neurons and pancreatic beta cells. GABA functional receptors (GABR) are expressed in brain, pancreas and peripheral blood lymphomononuclear cells (PBMC). After evaluating the differential gene expression in PBMC of recently diagnosed type 1 diabetes mellitus patients (T1D), three GABRA networks were observed, modulating the expression dozen of genes. The study was conducted on T (CD4+ a...

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GABA A receptor gene regulatory networks in peripheral blood TCD4+, TCD8+ AND CD14+ cells of recently diagnosed type 1 diabetes mellitus

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